Mesenchymal Stem Cells Kidney Regeneration

In search of innovative and effective strategies to foster the limited regeneration capacity of the kidney several studies have evaluated the ability of mesenchymal stem cells mscs of different origin as an attractive therapeutic tool.

Mesenchymal stem cells kidney regeneration.

Although intensive studies have been performed to isolate kidney stem progenitor cells from the mammalian adult kidney whether stem progenitor cells actually exist in the adult kidney is still debated. Mesenchymal stem cells mscs also known as mesenchymal stromal cells represent adult stem cell lineage of undifferentiated self renewable multipotent cells which originate from the mesoderm germ layer. Hickson is part of the research team looking at using stem cells to help regenerate failing kidneys. Mscs can differentiate into a wide range of different cells.

Found in the bone marrow these stem cells protect the kidneys from injury and accelerate healing. Mesenchymal stem cells seem to exert beneficial effects via paracrine effects rather than by direct differentiation into renal parenchymal cells. Mesenchymal stem cells are the body s natural defense against kidney damage. There are two types of stem cells treatments that may be utilized in our regenerative protocols for reversing renal failure.

Endogenous or lineage reprogrammed renal progenitor cells represent an attractive possibility for differentiation into multiple renal cell types. Different types of stem cells ranging from mesenchymal stem cells mscs 1 2 adipose stem cells adscs 3 amniotic fluid stem cells afscs 4 5 renal progenitors rps 6 7 and so forth can stimulate renal repair in vivo in models of acute and chronic. Several types of stem cells such as bone marrow derived cells adipocyte derived mesenchymal stem cells embryonic stem cells and induced pluripotent stem cells are also applied for renal regeneration. Different types of stem cells ranging from mesenchymal stem cells mscs 1 2 adipose stem cells adscs 3 amniotic fluid stem cells afscs 4 5 renal progenitors rps 6 7 and so forth can stimulate renal repair in vivo in models of acute and chronic kidney failure.

These stem cells act in part as modulators of fibrotic inflammatory. Mesenchymal stem cells in the treatment of acute kidney injury. Stem cell transplants for renal failure help to replenish the required kidney cells and thus promote a more normal healthy kidney function. Harvard stem cell institute scientists have identified protein candidates secreted from mesenchymal stem cells that may be administered independently to aid in kidney.

The results obtained in several models of aki and ckd document that mscs have therapeutic potential in. Our goal is to take a look at how we can repair the diabetic kidney in terms of delaying the rate of progression of kidney failure says latonya hickson m d a mayo clinic nephrologist.